گزارش یک مورد کارسینوم سلول های سنگفرشی ناحیه میان دو راه (Perineum) در گاو

نوع مقاله : مقاله پژوهشی

نویسنده

دانشکده دامپزشکی دانشگاه آزاد اسلامی واحد گرمسار

چکیده

یک گاو ماده 5 ساله با تاریخچه شکل گیری یک توده نامنظم، گل کلمی و السراتیو در ناحیه میان دوراه (perineum) به بیمارستان تخصصی دانشکده دامپزشکی دانشگاه آزاد اسلامی واحد گرمسار ارجاع داده شد. توده بافت توموری که در سمت چپ ناحیه (perineum) قرار گرفته بود به دیواره سمت چپ vulva و anus امتداد یافته و این دو قسمت را هم درگیر کرده بود. توده توموری توسط جراح از پایه برداشته شد. سطح خارجی آن کاملا سیاه رنگ، ناصاف و السراتیو و سطح مقطع قهوه ای - خاکستری با کانون های چرک و قوامی گوشتی و نسبتا سفت مشاهده گردید. شکل گیری توده توموری از 3 ماه قبل از ارجاع به کلینیک آغاز و به تدریج افزایش سایز پیدا کرده بود. غدد لنفاوی اطراف نرمال بودند و مدرکی مبنی بر لزیون های جلدی دیگر یا متاستاز به اندام های دیگر مشاهده نشد. مطالعات هیستوپاتولوژیک حضور کارسینوم سلول های سنگفرشی به خوبی تفکیک و تمایز یافته که در آن ها سلول ها در حلقه های متحدالمرکز قرار گرفته و کانون مرکزی متشکل از کراتین بدون سلول تحت عنوان مروارید کراتینی "KeratinPearl" را احاطه کرده بودند، مشاهده شد.
سلول های توموری، بزرگ، دارای سیتوپلاسم ائوزینوفیلیک فرارون با هسته های هیپرکروماتیک نسبتا بزرگ مشاهده شدند . سلول های توموری هیپرکروماتینیزم و اشکال میتوز را در نواحی بسیاری نشان دادند. بر اساس خصوصیات هیستوپاتولوژیک، تومور مذکور یک SCC تشخیص داده شد.

کلیدواژه‌ها


عنوان مقاله [English]

Perineal Squamous Cell Carcinoma in a Cow: A case Report

نویسنده [English]

  • Keivan Jamshidi
چکیده [English]

A 5-year old female cow with history of an irregularly shaped and cauliflower-like ulcerated mass was presented to the specialized veterinary hospital, IAU Garmsar Branch. The tumor mass tissue which was located at the left region of the perineum was extended to the right aspect of the vulva and anus and could affected these two regions. The mass was excised from the base by surgeon. The external surface of the mass was completely black, coarse and ulcerative, but on cut surface it appeared grayish-brown with focal purulent areas and fleshy texture and approximately consolidated. The tumor mass tissue formation appeared 3 months earlier to presentation yo clinic as a small neoplastic tissue, and gradually increased in size. The peripheral lymph nodes were normal and there was no evidence of another cutaneous lesion or of metastasis to other organs. Histopathologic examination revealed a well differentiated squamous cell carcinoma in which cells were located in centrifugal circles and surrounding a central acellular pearl of keratin "KeratinPearl" .The tumor cells were large and had an abundant eosinophilic cytoplasm with slightly enlarged hyperchromatic nuclei. They have produced large amounts of keratin, resulting in the formation of extracellular keratin pearls. Tumor cells showed hyperchromatism and mitotic figures in many areas. Based on histopathological characteristics the tumor was diagnosed as squamous cell carcinoma.

کلیدواژه‌ها [English]

  • cow
  • perineum
  • squamous cell carcinoma
Abu-Seida, A. M., 2015. Congenital cutaneous squamous cell carcinoma in a lamb. Asian Journal of Animal Sciences, 9, 80–84.
Abu-Seida, A. M. & A. A. Kawkab, 2007. External neoplasm in goats. A clinicopathological study of five types. Veterinary Medical Journal (Giza), 55, 33–44.
Anderson, D. E. & M. Badzioch, 1991. Association between solar radiation and ocular squamous cell carcinoma in cattle. American Journal of Veterinary Research, 52, 784–788.
Bancroft, JD and Marilyn, G (2007). Theory and practice of histological techniques. 6th Edn., UK, Elsevier-Health Sciences Division. PP: 250-260.
Evans, W. C., M. C. Patel & K. Koohy, 1982. Acute Bracken poisoning in homogastric and ruminant animals. Proceedings of the Royal Society Edinburg, 81, 29–64.
Farjanikish G. 2016. Perineal Squamous Cell Carcinoma in a Goat: A case Repor Bulgarian Journal of Veterinary Medicine, ISSN 1311-1477; DOI: 10.15547/bjvm.976
Fayza, A. O., O. M. Ahmed & H. Hamaad, 2006. A note on squamous cell carcinoma in a Saanen goat. The Sudan Journal of Veterinary Research, 21, 93–95.
Ford, J. N., P. A. Jennings, P. B. Spradbrow & J. Francis, 1982. Evidence for papillomaviruses in ocular lesions in cattle. Research in Veterinary Science, 32, 257–259.
Galera, P. D. & E. N. Martins, 2001. Superficial keratectomy in ocular squamous cells carcinoma in Simmental cattle: A case report. Arquivo Brasileiro de Medicina Veterinária, 53, 585–588.
Ginn, P. E., J. L. Mansell & P. M. Rakich, 2007. Skin and appendages. In: Pathology of the Domestic Animals. 5th edn., vol. 1, eds K. V. F. Jubb, P. C. Kennedy & N. C. Palmer, W. B. Saunders Co., Philadelphia. pp. 751–753.
Goldschmidt, M. H. & M. J. Hendrick, 2002. Tumors of the skin and soft tissues. In: Tumors in Domestic Animals, 4th edn, ed D. J. Meuten, Iowa State Press, Ames, pp. 45–118.
Kusewitt, D. F. & L. J. Rush, 2007. Neoplasia and tumor biology. In: Pathologic Basis of Veterinary Disease, eds M. D. McGavin & J. F. Zachary, Mosby Elsevier, St. Louis, pp.1263–1315.
Ladds, P. W. &K. W. Entwistle, 1977. Observations on squamous cell carcinoma of sheep in Queensland, Australia. British Journal of Cancer, 35, 110–114.
Mara, M., G. Diguardo, A. Venuti, G. Marrachella, C. Palmieri, M. De Rugeriis, L. Petrizzi, P. Simeone, C. Rizzo & D. L. Salda, 2005. Spontaneous ocular squamous cell carcinoma in twin goats: Pathological and biomolecular studies. Journal of Comparative Pathology, 132, 96–100.
Mendez, A., J. Perez, E. Ruiz-Villamor, R. Garcia, M. P. Martin & E. Mozos, 1997. Clinicopathological study of an outbreak of squamous cell carcinoma in sheep. The Veterinary Record, 141, 597–600.
Meuten, D. J., 2002. Tumors in domestic animals, 4th edn. Iowa State Press, Ames, pp. 52–54.
Radostits, O. M., C. C. Gay, K. W. Hinchcliff & P. D. Constable, 2007. Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs, and Goats, 10th edn, Elsevier Saunders, Edinburgh, pp. 596–597.
Ramos, A. T., D. M. Norte, F. Elias & C. G. Fernandes, 2007. Squamous cell carcinoma in cattle, sheep and horse. Study of 50 cases in south of Rio Grande do Sul. Brazilian Journal of Veterinary Research and Animal Science, 44, 5–13.
Rezaie, A., H. Golshahi & H. Naddaf, 2012. Coincidence of meibomian adenoma and squamous cell carcinoma in the upper eyelid of a sheep: Histopathological and immunohistochemical studies. Iranian Journal of Veterinary Research, 13, 343–346.
Rutten, V. P., W. R. Klein, M. A. De Jong, W. Quint, W. Denotter, E. J. Ruitenberg & W. J. Melchers, 1992. Search for bovine papilloma virus DNA in bovine ocular squamous cell carcinomas (BOSCC) and BOSCC-derived cell lines. American Journal of Veterinary Research, 53, 1477– 1481.
Stannard, A. A. & L. T. Pulley, 1978. Tumor of the skin and soft tissue. In: Tumors in Domestic Animals, 2nd edn, ed J. E. Moulton, University of California Press, Berkeley, Los Angeles, USA.
Swan, R. A., H. M. Chapman, C. D. Hawkins, J. C. Howell, & V. T. Spalding, 1984. The epidemiology of squamous cell carcinoma of the perineal region of sheep: Abattoir and flock studies. Australian Veterinary Journal, 61, 146–151.
Uzal, F. A., A. Latorraca, M. Ghoddusi, M. Horn, M. Adamson, W. R. Kelly & R. Schenkel, 2000. An apparent outbreak of cutaneous papillomatosis in merino sheep in patagonia, Argentina. Veterinary Research Communications, 24, 197–202.
Vanselow, B. A. & P. B. Spradbrow, 1983. Squamous cell carcinoma of the vulva, hyperkeratosis and papillomaviruses in a ewe. Australian Veterinary Journal, 60, 194–195.
Withrow, S. J. & D. M. Vail & E. G. Madewell, 2012. Small Animal Clinical Oncology, 5nd edn, W. B. Saunders Company, Philadelphia, pp. 66.
Zabady, M. K., A. M. Abu-Seida & K. A. Ahmed, 2004. Clinicopathological study on cutaneous scc and papilloma in sheep. Veterinary Medicine Journal of