نوع مقاله : مقاله پژوهشی
عنوان مقاله English
نویسندگان English
Benign prostatic hyperplasia (BPH) is common in aged dogs, and systemic inflammation plays a key role in its pathogenesis. Platelet indices (PLT, PCT, MPV, PDW) and their derived ratios (MPV/PLT, MPV/PCT, MPV/PDW) are markers of platelet activation. This study investigated their changes in experimentally induced canine BPH and the therapeutic effects of finasteride and melatonin. Twenty‑three healthy male dogs were divided into five groups: BPH + finasteride, BPH + finasteride + melatonin, BPH positive control, melatonin alone (healthy), and negative control (healthy). BPH was induced by testosterone and estradiol injection over 63 days, followed by 28 days of treatment. Blood samples were collected at four time points and analyzed using non‑parametric tests. After induction, BPH groups showed a significant decrease in PCT and PLT and a significant increase in MPV and PDW; moreover, the MPV/PCT ratio increased significantly in all three induced groups. During treatment, MPV decreased in both the finasteride and finasteride + melatonin groups. Experimental induction of BPH was associated with significant alterations in platelet indices as well as the MPV/PLT and MPV/PCT ratios. Finasteride treatment partially attenuated these changes. Although changes in some parameters were also observed in the melatonin-treated group, these did not result in a statistically significant advantage over finasteride treatment alone.
کلیدواژهها English
