نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشکده دامپزشکی، دانشگاه سمنان، سمنان، ایران
2 گروه علوم بالینی، دانشکده دامپزشکی، دانشگاه سمنان، سمنان، ایران
3 دانشجوی دکترای دامپزشکی، دانشکده دامپزشکی، دانشگاه سمنان، سمنان، ایران،
4 دانشجوی دکترای دامپزشکی، دانشکده دامپزشکی، دانشگاه سمنان، سمنان، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Platelet-rich plasma (PRP) contains high concentrations of platelets and growth factors that promote tissue repair by stimulating angiogenesis, recruiting stem cells, and modulating cellular activity. Both autologous PRP (derived from the patient) and heterologous PRP (donor-derived from the same species) have been effective in treating corneal injuries such as keratitis and corneal erosions. Heterologous PRP, particularly when obtained from blood banks, provides an accessible alternative, and studies have confirmed its safety.
This case series evaluated the use of canine-derived heterologous PRP in treating corneal ulcers in three FHV-1-infected kittens. Due to the unavailability of autologous PRP, dog-sourced PRP was used as adjunctive therapy alongside standard treatments (antibiotics, antivirals, and artificial tears). Clinical signs included symblepharon and corneal sequestra, with ultrasound confirming corneal edema and secondary uveitis.
Significant improvement in ulcer healing suggested the potential efficacy of interspecies PRP. Unvaccinated kittens exhibited more severe disease, and in one case, conjunctival flap surgery was required due to owner non-compliance. The findings indicate that heterologous PRP, including interspecies preparations, may be a promising alternative when autologous PRP is unavailable. However, further research is needed to validate its safety and efficacy. Strict adherence to veterinary protocols remains essential to prevent complications and ensure optimal outcomes
کلیدواژهها [English]
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