Therapeutic effect of Tymasin plus in experimental model of cerebral ischemia

Document Type : Original Article

Authors

1 Department of Basic sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

2 Division of Physiology, Department of Basic sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

3 Department of basic sciences, Faculty of Veterinary Medicine, Semnan University, Semnan. Iran

4 Department of clinical sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

5 Department of pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Abstract

Acute ischemic brain damage, which is caused by the reduction of blood supply to the brain or the blockage of cerebral vessels, is one of the important causes of death, disability, and behavioral and cognitive disorders in humans all over the world. Tymasin Plus(TP) is an Iranian herbal medicine manufactured by Medin Pharma for some respiratory diseases in humans. In this study, the effect of the mentioned drug on spatial memory and explorative behavior of laboratory animals after experimental cerebral ischemia was investigated. 24 male Wistar rats were divided into 4 experimental groups including control, ischemic, recipients of 0.5 ml and 1 ml of TP. Animals in the control group were not subjected to any intervention. In order to create experimental temporary cerebral ischemia in the ischemic and TP administrated groups, surgery was done on rats and then the ischemic group received normal saline and the TP administrated groups received the mentioned drug. Spatial memory was investigated using Morris Water Maze test, exploratory behavior via open field test and rat brains were examined histopathologically. The results of Morris water Maze and open field tests as well as histopathological results, showed significant differences between the ischemic and control groups. The TP administrated groups compared with ischemic group had significant differences in terms of Morris Water Maze test (1 ml TP administrated group) and histopathological evaluations. Based on the results of this research, it can be concluded that TP has therapeutic effect on the cerebral ischemic induced spatial memory impairment and also has neuroprotective effect.
 

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References

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Journal of Veterinary Laboratory Research
Volume 17, Issue 1 - Serial Number 27
in processing
April 2025
Pages 29-40

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