Malignant Adrenal gland Pheochromocytoma in a 9 -year-old femaleShih tzu dog

Document Type : Original Article

Authors

1 Department of Clinical Sciences, Faculty of Specialized Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran- Iran

2 Hamidreza fattahiam pet hosoiral, department of pathology

3 Department of Internal Medicine, Hamidreza Fattahian Small Animal Hospital, Tehran- Iran

4 Department of Diagnostic Imaging, Hamidreza Fattahian Small Animal Hospital, Tehran- Iran

5 Department of surgery, Hamidreza Fattahian Small Animal Hospital, Tehran- Iran

6 Department of Pathology, Hamidreza Fattahian Small Animal Hospital, Tehran- Iran

Abstract

Pheochromocytomas are tumors of the adrenal medulla that affect chromaffin cells. These tumors are not common in dogs but may occur in older dogs with no specific breed noted. They can be solitary or bilateral, functionally active or inactive, benign or malignant. They are malignant if have long-distance metastasis to other organs such as spleen, lung, regional lymph nodes, bone, and CNS. A 9 -9-year-old spayed female Shih Tzu dog was present at Small Animal Hospital with a history of generalized weakness, anorexia, and depression. In ultrasonography, unilateral enlargement of the left adrenal gland was seen and by surgery, the left adrenal gland was removed.Cytologic evaluation by Giemsa staining showed neoplastic polygonal cells with anisokaryosis.
Histopathologic study on tissue specimen revealed a large mass composed of polygonal, uniform vacuolated cells with granular red cytoplasm. Pigmented granules containing hemosiderin and melanin were present in neoplastic cells.
According to diagnostic ultrasonographic and pathologic findings, this tumor was diagnosed as pheochromocytoma. This clinical report aims to report the diagnosis and successful treatment of pheochromocytoma tumor by surgical method in a 9-year-old Shih Tzu dog and to describe the pathological features of this rare mass.
 

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Journal of Veterinary Laboratory Research
Volume 15, Issue 2 - Serial Number 24
September 2023
Pages 213-218

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