Investigating the antidiabetic effects of concurrent versus separate administration of coenzyme Q10 and L-Arginine in diabetic rats

Document Type : Original Article

Authors

1 UNI Zabol

2 ظشذخم

3 Uni Zabol

Abstract

Coenzyme Q10 (CoQ10) is an essential cofactor for cellular energy production, while L-arginine is a substrate of nitric oxide synthesis that have metabolic effects. This study aimed to evaluate the separate versus combined effects of CoQ10 and L-arginine on diabetic biomarkers in rats. Forty-eight male rats weighing 180-250 gr were randomly divided into six groups: The first healthy control group, the second diabetic control group (untreated diabetes), the third diabetic treated group with L-arginine (50 mg/kg), the fourth diabetic treated group with CoQ10 (10 mg/kg), the fifth diabetic treated group with L-Arginine (50 mg/kg) and CoQ10 (10 mg/kg), the sixth diabetic treated group with Metformin (250 mg/kg). Type 1 diabetes was induced with Alloxan (120 mg/kg, IP). After 30 days, glucose, insulin, liver enzymes, urea, serum creatinine and glycosylated hemoglobin (HbA1c) were measured. Data were analyzed using the sigma stat 3.5 test with a significance level of P<0.05. In the CoQ10-treated group, HbA1C, serum glucose, liver enzymes, insulin, BUN, and creatinine were significantly decreased (P<0.05). L-arginine also demonstrated similar effects on serum biochemical parameters. However, no synergistic effect was observed between CoQ10 and L-arginine, suggesting that their combined use in diabetic patients may not be beneficial. According to the findings of the present study, CoQ10 Administration in conjunction with metformin may offer advantageous therapeutic outcomes.

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