First report of a renal cell carcinoma in cattle in Iran

  Abstract:     Carcinoma is the most common primary renal tumor in cattle, dog and horse. In cattle, aged females are more susceptible than males. Bilateral renal involvement is common and rate of systemic metastasis is low. The present study was performed in a Holstein cow in Najaf Abad abattoir of Isfahan. Swelling and hardness in consistency of the kidneys and neoplastic foci of various sizes, white to yellow in color that swelled up from the surface of the kidney were seen in macroscopic examination. For microscopic examination tissue samples prepared from the lesions and were sent to the lab in 10% buffered formalin. Sections were prepared from samples and were stained using hematoxylin and eosin (H-E). In histopathology, the presence of neoplastic foci with fibrous and collagenous stroma, polygonal or oval neoplastic cells with eosinophilic and foamy cytoplasm, clear neoplastic cells with round or oval eccentric nucleus and dense chromatin network and absence of fetal renal structures, renal cell carcinoma was diagnosed. This report seems to be the first case of bovine renal cell carcinoma in Iran.