Study of drug resistance patterns of separated Clostridium perfringens from broiler in Fars province

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AbstractClostridium perfringens is a thick, gram positive and long bacteria (basil) that is seen in single or double. It is rarely like chain. Type C and D toxins of Clostridium cause necrotic enteritis in broiler. It is also cause enteric toxin in human. The aim of this study was to determine drug resistance patterns of separated Clostridium perfringens in broiler. Antibiogram test was performed after separation of 22 strains of Clostridium perfringens from broiler of Fars province and sensitivity to penicillin, chloramphenicol and vancomycin was recorded. Results were analyzed by using statistical software SPSS17. In this research, sensitivity in all 22 isolates of Clostridium perfringens to penicillin, vancomycin and chloramphenicol was 81.3 percent to 88.2 percent, while in the other antibacterial compounds such as tetracycline, lincomycin, neomycin sulfate resistance showed a 71% to 85%. Furthermore, all isolates showed resistance to more than one anti-bacterial compound. Also there was statistically significant difference (P ≤ 0.05) between susceptible isolates and resistant isolates. According to drug resistance of Clostridium perfringens isolates to antibiotics tetracycline, lincomycin, neomycin sulfate before antibiotic prescription, antibiogram tests are required.

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