Canine Heterologous Platelet-Rich Plasma (PRP) for the Management of FHV-1 Associated Corneal Ulcers in Three Cats

Document Type : Original Article

Authors

1 Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

3 DVM student, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran,

4 DVM student, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

10.22075/jvlr.2025.37879.1171

Abstract

Platelet-rich plasma (PRP) contains high concentrations of platelets and growth factors that promote tissue repair by stimulating angiogenesis, recruiting stem cells, and modulating cellular activity. Both autologous PRP (derived from the patient) and heterologous PRP (donor-derived from the same species) have been effective in treating corneal injuries such as keratitis and corneal erosions. Heterologous PRP, particularly when obtained from blood banks, provides an accessible alternative, and studies have confirmed its safety. This case series evaluated the use of canine-derived heterologous PRP in treating corneal ulcers in three FHV-1-infected kittens. Due to the unavailability of autologous PRP, dog-sourced PRP was used as adjunctive therapy alongside standard treatments (antibiotics, antivirals, and artificial tears). Clinical signs included symblepharon and corneal sequestra, with ultrasound confirming corneal edema and secondary uveitis. Significant improvement in ulcer healing suggested the potential efficacy of interspecies PRP. Unvaccinated kittens exhibited more severe disease, and in one case, conjunctival flap surgery was required due to owner non-compliance. The findings indicate that heterologous PRP, including interspecies preparations, may be a promising alternative when autologous PRP is unavailable. However, further research is needed to validate its safety and efficacy. Strict adherence to veterinary protocols remains essential to prevent complications and ensure optimal outcomes.
 

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Main Subjects

References

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Journal of Veterinary Laboratory Research
Volume 17, Issue 2 - Serial Number 28
In Progress
October 2025
Pages 201-211

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