Radiographic investigation of the effects of platelet-rich plasma on bone repair in femoral head osteotomy (FHO) in rabbits

Articles in Press

Document Type : Original Article

Authors

1 Department of Basic Sciences, D.V.M. Graduate, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

2 Department of basic sciences , Faculty of veterinary Medicine , Semnan University , Semnan- iran .

3 Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

4 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

10.22075/jvlr.2026.39277.1190

Abstract

Platelet-rich plasma (PRP) has emerged as a promising adjunct in musculoskeletal regenerative therapies. The FHO limits the bony contact between the femoral head and the acetabulum and allows the formation of a fibrous pseudoarthrosis. This study aimed to evaluate the radiographic effects of PRP on bone repair following femoral head osteotomy in rabbits. Eighteen adult male New Zealand White rabbits were randomly divided into two equal groups: a treatment group and a control group. Blood was collected from the hearts of the treatment group in a tube containing anticoagulant in an amount of 6 cc, and after two centrifugation steps with CaCl2, the autologous PRP was activated. For each rabbit in the treatment group, 1.5 ml of PRP was prepared and added at the surgical site. Standardized radiographic assessments were performed at 2, and 3 weeks postoperatively to evaluate callus formation, area of periosteal reaction, and degree of changes in the acetabulum. The PRP-treated group demonstrated significantly enhanced radiographic signs of bone regeneration, including earlier onset of callus formation and improved periosteal reaction, and the degree of changes in the acetabulum compared to controls. These findings suggest that PRP accelerates early bone healing and improves structural integrity post-FHO, potentially supporting its use in orthopedic surgical practice. The presence of high concentrations of growth factors in platelet-rich plasma to accelerate bone repair and pseudo-joint formation by reducing joint inflammation can be effective in faster weight gain in cases requiring hip arthroplasty. More histological studies are recommended to confirm these results

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Journal of Veterinary Laboratory Research

Articles in Press, Accepted Manuscript
Available Online from 19 January 2026

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