Evaluation of anticonvulsive effect of Thymus vulgaris extract in rat

Document Type : Original Article

Authors

1 Department of Basic sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

2 Dentist,, MSc in animal physiology and neuroscience,, Italy

Abstract

Thyme is one of the medicinal plants with various therapeutic properties mentioned in traditional medicine. In this research, male Wistar rats were divided in 4 experimental groups. 3 groups received Thymus vulgaris aqueous extract (1000, 2000 and 4000 microgram per microliter) intracerebroventriculary. Also in control group, normal saline (1microliter) was injected intracerebroventriculary. Then, in order to induce convulsions in all experimental groups, pentylentetrazol (80mg/kg) was injected intraperitoneally. The results showed that the injection of 1000 microgram extract significantly reduces the depth of seizure compared to the control group and causes significant increase of initiation time of fifth convulsive stage. Also, injection of 2000 microgram extract caused a significant increase of initiation time of third and fourth convulsive stages compared to the control group. On the other hand, the injection of 4000 microgram extract did not show any significant difference compared to the control group. These results show that the aqueous extract of Thymus vulgaris has anticonvulsant properties.
 

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References

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Journal of Veterinary Laboratory Research
Volume 15, Issue 2 - Serial Number 24
September 2023
Pages 203-211

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